![]() Asia Pacific Association for the Study of the Liver Renal transplantation from a donor with undiagnosed Class V lupus nephritis demonstrates prolonged histopathologic features of lupus nephritis despite absence of SLE in recipients.ĭecreased activity of endothelial V3 integrin in the Cd39-null mouse is associated with defective tumor angiogenesis.Ĥth International Symposium of Nucleosides and Nucleotides.Purines 2004ĭisordered Liver Regeneration and Defective Angiogenesis in NTPDase1/Cd39-Null Mice. Marginal zone defects in Wiskott-Aldrich syndrome are dependent on B cell intrinsic TLR signals.įederation of Clinical Immunology Societies meeting (FOCIS 2012) Keystone Symposium, "B Cell Development and Function". Trypanosoma cruzi trans-sialidase initiates an ROR-t independent program leading to high-level IL-17 production by activated B cells. Opposing impact of B cell intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation. The B Cell Survival Cytokine BAFF Promotes Murine Lupus Nephritis via Activation of TACI, Not BAFF Receptor.ī Cell-Intrinsic Deletion of the Type 1 Interferon Receptor Does Not Impact the Development of Murine Lupus. The B Cell Survival Cytokine BAFF Promotes Systemic Lupus Erythematosus Via Activation of TACI, Not BAFF Receptor His research has resulted in a number of new insights into the B cell-intrinsic signals underlying lupus pathogenesis and has lent support to an emerging paradigm of humoral autoimmunity in which B cells orchestrate initial breaks in immune tolerance.ī Cell-Intrinsic Interferon Gamma Signals Promote the Development of Systemic Lupus Erythematosus By Enhancing the Formation of Spontaneous Autoimmune Germinal CentersĪmerican College of Rheumatology (ACR) annual meetingī Cell-Intrinsic Interferon Gamma (IFN-) Signals Promote B Cell Activation and the Development of Lupus NephritisĪmerican Society of Nephrology (ASN) Kidney Week Jackson’s research aims to improve our understanding of the immune pathogenesis of human autoimmune diseases, in particular the role for B cells in Systemic Lupus Erythematosus (SLE). He completed dual pediatric nephrology and rheumatology fellowship training at Seattle Children's Hospital / University of Washington.ĭr. After receiving his medical degree from the University of Cape Town in South Africa, he undertook post-doctoral studies in vascular biology at Harvard Medical School and completed pediatric residency training at Boston Children's Hospital. ![]() Shaun Jackson, MD, PhD, is an attending physician in Pediatric Nephrology and Pediatric Rheumatology at Seattle Children's Hospital and an Associate Professor of Pediatrics of Pediatrics at the University of Washington School of Medicine.
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